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A 54-year-old insulin-dependent diabetic notes that her insulin requirements have gone up dramatically in the past year (from 50 U to nearly 200 U of recombinant human insulin) and her blood glucose is still poorly controlled. A possible explanation for the worsening of her diabetes includes which of the following?


A) a high titer of anti-insulin antibodies
B) an improved diet
C) an improved exercise program
D) progression of macrovascular disease
E) weight loss

F) C) and D)
G) A) and B)

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