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Exam 3: Routes of Drug Delivery

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Question 1

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The intra - articular injection is given for treatment of erectile dysfunction in men.

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B) False

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False

Question 2

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Name the drug that was first approved by U.S FDA for transdermal patch.

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For administration of large polar molecules (<1000 DA) via the nasal route,penetration enhancers are used to ensure good bioavailability.

Epithelial cells of the GI tract assist in the diffusion of most drug molecules.

Sublingual route is popularly used for which of the following? (More than one answer may be correct.)

Using an example,illustrate how drug absorption is affected by food.

Mention the three modes by which micro-needles are used for transdermal drug delivery.

Fill in the blank: Drugs after aerosol administration is deposited by three mechanisms,in which __________ helps for deposition of smaller particles,whereas larger particles are deposited by both gravitational sedimentation and __________

Chitosan,a mucoadhesive polymer,decreases the bioavailability of drugs.

Compare and contrast the oral and parenteral administration of drugs.

Administration of drugs by the intramuscular route offers uniform and slow drug absorption.

List the possible reasons for efficient delivery of drugs via the respiratory system:

Oral route is better than transmucosal route for delivery of protein and peptide drugs.

Name a few alternative approaches of drug delivery by transdermal route.

Name the most relatively impermeable layer of epidermis.

Contrast transcellular and paracellular transport.

A drug from the alveoli is slowly absorbed when compared to the airways of the lungs.

Compare and contrast the alternative approaches: Ionotophoresis and Sonophoresis.

Order the five layers of the epidermal layer: ___ stratum basale ___ stratum granulosum ___ stratum corneum ___ stratum lucidum ___ stratum spinosum

Using an example,explain why PEGylation improves the safety profiles of proteins.